Mucormycosis of the nose and paranasal sinuses. The most common sites of infection are rhino-orbital-cerebral and pulmonary and typically occur in immunocompromised hosts and diabetics 2.
Otolaryngology Clinics of North America. Current Infectious Disease Reports. Scotch tape prep showing broad hyphae with rare septation and round sporangia. Current Opinions in Infectious Diseases.
These features, paired with the morphology of the sporangia are diagnostic for a Zycomycete; further identification was attempted however, rhizoids characteristic of Rhizopus, and branching characteristic of Mucor were not identified in this culture.
Facial numbness can occur if there is infarction of sensory branches of the fifth cranial nerve. The Zygomycetes are also known to invade blood vessels making tissue infarction and necrosis one of the hallmarks of the disease 3.
In some situations removal of the palate, nasal cartilage, and orbit are necessary for cure. In immunocompromised patients, the spores can settle in the nasal turbinates and alveoli causing disease 1.
The patient continued to have chest pain and coughing, so the decision was made to proceed with bronchoscopy Laboratory Identification Image 1. If infection spreads from the sphenoid sinuses to the adjacent cavernous sinus, it can result in cranial nerve palsies, thrombosis of the sinus, and involvement of the carotid artery 4.
Infections are treated with a combination of antifungal drugs such as Amphotericin B, and aggressive surgical debridement.
In patients with pneumonia, often lobectomy is needed for cure 5. He has had low grade fevers for the past several days but denies chills, sweats, or hemoptysis.
Author Lablogatory Posted on. Annals of Thoracic Surgery. Cultures from the BAL revealed a rapidly growing fungi with broad hyphae 5 to 15 micron diameter that are irregularly branched, and have rare septations. The infection can spread to contiguous structures, such as the mediastinum and heart, or disseminate hematogenously to other organs such as the GI tract, kidney, and brain 5.
The genera most commonly found in human infections are Rhizopus, Mucor, and Rhizomucor. When the spores are inhaled into the lung, pneumonia with infarction and necrosis results.
This unique collection of 55 multidisciplinary case studies enables students to better integrate material from all the major clinical laboratory disciplines-Blood Bank, Chemistry, Hematology, Immunology, Microbiology, Urinalysis-by giving them the opportunity to "experience" how departments work together to help the physician make a diagnosis and determine the best course of treatment for the patient.
Unlike traditional case studies that are based solely on the medical model with patient history followed by questions leading to the diagnosisthese cases not only correlate results with disease states, but serve as problem-solving and critical-thinking exercises based on real scenarios that occur in typical clinical laboratories.
Typically, the spores are transported by the muco-cilliary escalader to the pharynx, are swallowed, and then are broken down by the GI tract. Pathophysiology, etiology and epidemiology are naturally reviewed as a case unfolds, and students deal firsthand with interpreting data from two, three or four disciplines, challenging them to integrate laboratory data from different departments and to think critically about what they mean.
Discussion Zygomycetes Mucormycetes are widely distributed in the environment in soil and vegetation and infection is through inhalation of spores.
Because of this rapid growth, infection with Zygomycetes typically progress quickly and cause periorbital edema, proptosis, and blindness.
Mucor is more likely to have branching and is often identified when all other species are ruled out; they do not produce a rhizoid.Tag: case studies Microbiology Case Study: A 14 Year Old Immunocompromised Male with Pneumonia Case History and Laboratory Findings.
JMM Case Reports2 (). Manual of Clinical Microbiology, 11 th edition -Erin McElvania, PhD, D(ABMM), is the Director of Clinical Microbiology NorthShore University Health System in Evanston.
CASE STUDIES FOR THE LABORATORY PROFESSIONAL Clinical Laboratory Science.
American Society for Clinical Laboratory Science International Drive, Suite McLean, VA billsimas.com 3 CLINICAL LAB INVESTIGATIONS: CASE STUDIES FOR THE LABORATORY PROFESSIONAL. Each month, a case and a series of questions can be emailed to interested individuals weeks in advance of publication.
Medical Laboratory Science Case Studies - Overview Each case study presents a case, often rare in nature, discussing its pathogenesis, clinical and laboratory diagnosis, treatment, and prognosis. This program is intended for individuals who wish to maintain laboratory certification, or for those interested in staying current in the ever.
A list of courses offered by the Clinical Laboratory Sciences Program at UTMB, with links to course descriptions and online content. Case-Studies-Clinical-Laboratory-Sciencepdf - Free download as PDF File .pdf), Text File .txt) or read online for free.1/5(2).Download